Coordinator of HEDIMED. Professor Heikki Hyöty’s team has a long experience from studies evaluating the role of microbes in the pathogenesis of T1D, and interactions between microbes and the immune system. Hyöty’s group is responsible for virome analysis, virus antibodies, production of recombinant microbial proteins for arrays, cytokines and allergen-specific IgE and volatilomics.
The group is also partially responsible for the collection and maintenance of samples and data of the prospective DIPP birth cohort study and the PREVALL trial. Tasked with the administration of the HEDIMED consortium, the team coordinates the interactions of stakeholders.
Heikki Hyöty is a co-principal investigator and a steering committee member of the DIPP study, a co-principal investigator of the PREVALL trial and the coordinator of the Virdiab and FinKarelia studies.
Type 1 diabetes, enteroviruses, allergy, prospective studies, virome, antibodies, virus detection, virus serology, microbiome, vaccines
Project coordinator, Professor of Virology, Faculty of Medicine and Health Technology, Tampere University
TAMPERE CELIAC DISEASE STUDY GROUP
The representatives of the Tampere Celiac Disease Group, Prof. Kalle Kurppa and Prof. Katri Lindfors, have a long experience on studies about celiac disease and other gluten-related disorders. The group has published a high number of both pediatric and adult studies, the focus ranging from epidemiological and clinical studies to genetics, immunobiology, microbiology and bioinformatics. The main of the group is to advance the current understanding of gluten-induced disease entities applying multidisciplinary approach.
In Hedimed the group is responsible for the screening and diagnostics of celiac disease, particularly in DIPP cohort. Kalle Kurppa is a steering committee member of the DIPP study.
Celiac disease, autoantibodies, gut biology, histology, genetics
M.D., Ph.D., Professor of Pediatrics, Tampere University and Tampere University Hospital, Tampere, Finland
M.D., Ph.D., Associate Professor, Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University
COMPUTATIONAL BIOLOGY GROUP
Professor Matti Nykter’s group develops algorithms and computational models for biomedical applications. The group favors a data-driven approach which often begins with the acquisition of high throughput genomic, epigenomic, transcriptomic and/or proteomic data. The group then analyses the data computationally in an effort to better understand the biological processes and networks driving a disease or phenotype. The generated hypotheses are then validated and refined in collaboration with experimentally inclined research groups.
Computational Biology group is part of Academy of Finland Center of Excellence in Tumor Genetics.
Bioinformatics, computational biology, statistical modelling, machine learning, computer science
Professor of Bioinformatics, Faculty of Medicine and Health Technology, Tampere University
INTESTINAL SIGNALLING AND EPIGENETICS GROUP
Adj. Prof Keijo Viiri’s group has a long experience on various intestinal organoid models and their applicability to model and execute functional studies in e.g. celiac disease. Work also entails genome-wide screening studies for gluten-induced enteropathies
In the Hedimed project the group is the work package leader in WP8 steering the work in the theme “Exposomic signature in cell and organoid models”
Intestinal biology, organoid models, epigenetics, genome-wide methods, celiac disease