Scientific Publications

Exposomic determinants of immune-mediated diseases – a special focus on type 1 diabetes, celiac disease, asthma and allergies; The HEDIMED project approach. Jutta E. Laiho, Olli H. Laitinen, Johannes Malkamäki, Leena Puustinen, Aki Sinkkonen, Juha Pärkkä, Heikki Hyöty and the HEDIMED Investigator group. Environmental Epidemiology, June 2022 – Volume 6 – Issue 3 – p e212, doi: 10.1097/EE9.000000000000021 https://journals.lww.com/environepidem/Fulltext/2022/06000/Exposomic_determinants_of_immune_mediated.6.aspx

Parechovirus Infection in Early Childhood and Association With Subsequent Celiac Disease. Tapia, German; Chudá, Kateřina; Kahrs, Christian R.; Stene, Lars C.; Kramna, Lenka; Mårild, Karl; Rasmussen, Trond; Rønningen, Kjersti S.; Cinek, Ondřej; Størdal, Ketil. The American Journal of Gastroenterology: April 2021 – Volume 116 – Issue 4 – p 788-795 doi:110.14309/ajg.0000000000001003 https://journals.lww.com/ajg/Fulltext/2021/04000

Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes. Noora Nurminen, Damiano Cerrone, Jussi Lehtonen, Anirudra Parajuli, Marja Roslund, Maria Lönnrot, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Juho Rajaniemi, Olli H. Laitinen, Aki Sinkkonen, Heikki Hyöty. Diabetes Care July 2021, 44 (7) 1506-1514; DOI: 10.2337/dc20-1719 https://care.diabetesjournals.org/content/44/7/1506

A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children. Marja I. Roslund, Anirudra Parajuli, Nan Hui, Riikka Puhakka, Mira Grönroos, Laura Soininen, Noora Nurminen, Sami Oikarinen, Ondřej Cinek, Lenka Kramná, Anna-Mari Schroderus, Olli H. Laitinen, Tuure Kinnunen, Heikki Hyöty, Aki Sinkkonen, ADELE research group. Ecotoxicol Environ Saf: 2022 August 2;242:113900. doi: 10.1016/j.ecoenv.2022.113900

Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome. Wisnu A. Wicaksono, Aisa Buko, Peter Kusstatscher, Tomislav Cernava, Aki Sinkkonen, Olli H. Laitinen, Suvi M. Virtanen,  Heikki Hyöty & Gabriele Berg. December 2022. Microbial ecology, 10.1007/s00248-022-02157-8. Advance online publication. https://doi.org/10.1007/s00248-022-02157-8

Modulation of the food microbiome by apple fruit processing. Wisnu Adi Wicaksono, Aisa Buko, Peter Kusstatscher, Aki Sinkkonen, Olli H. Laitinen, Suvi M. Virtanen, Heikki Hyöty, Tomislav Cernava, Gabriele Berg. Food Microbiology, Volume 108, December 2022, 104103. doi:https://doi.org/10.1016/j.fm.2022.104103

Effects of Lactiplantibacillus plantarum and
Lacticaseibacillus paracasei supplementation on the faecal metabolome in
children with coeliac disease autoimmunity: a randomised, double-blinded
placebo-controlled clinical trial. Eliska Jenickova, Carin Andrén Aronsson,
Anna Mascellani Bergo, Ondrej Cinek, Jaroslav Havlik, Daniel Agardh. Frontiers
in Nutrition. Volume 10 – 2023 https://doi.org/10.3389/fnut.2023.1183963

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort. Astrid Sevelsted, Casper-Emil Pedersen, Gözde Gürdeniz, Morten Rasmussen, Jörg Schullehner, Kalliroi Sdougkou, Jonathan W. Martin, Jessica Lasky-Su, Andreanne Morin, Carole Ober, Ann-Marie Schoos, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes & Hans Bisgaard. eBioMedicine, part of the Lancet Discovery Science. Volume 94, August 2023, 104699 https://doi.org/10.1016/j.ebiom.2023.104699 

Atopic sensitization in childhood depends on the type of green area around the home in infancy. Tiia Voor, Meelis Pärtel, Aleksandr Peet, Liisa Saare, Heikki Hyöty, Mikael Knip, John Davison, Martin Zobel, Vallo Tillmann. Clinical & Experimental Allergy.  Volume 53, Issue 8, August 2023. Doi:https://doi.org/10.1111/cea.14317