METAGENOMIC SEQUENCING GROUP
The main research interests of Ondrej Cinek’s team are infectious exposures in primarily non-infectious diseases, namely the characterization of viromes and bacteriomes and specific detection of relevant infectious agents. The groups is skilled in high-throughput real-time PCR virus assays, in virome sequencing and in 16S rDNA profiling of bacteriomes.
In Hedimed, the group is responsible for virome sequencing and for co-ordination of testing of specific external exposures, namely to infectious agents.
Virome sequencing and virus detection; bacteriome profiling; type 1 diabetes epidemiology; programming and bioinformatics
Professor in Medical Biology, 2nd Faculty of Medicine, Charles University and University Hospital Motol
Dr. Eva Fronkova´s team has a long experience in antigen receptor immunoprofiling from studies evaluating the role of B and T lymphocytes in immunodeficiency and lymphoid malignancies. The group participates in the development of standardized immunoglobulin and T-cell receptor profiling via next-generation sequencing (NGS) aimed at minimal residual disease testing in lymphoid neoplasia. This method can be also used for highly sensitive tracking of multiple T-cell clones in patients with autoimmunity. Another focus of our team is the discovery of new genetic causes in patients with immune dysregulation.
Dr. Fronkova´s team is responsible for T-cell receptor profiling in Hedimed cohorts.
T-cell receptor gene, immunoglobulin, immunodeficiency, immune dysregulation, lymphoid neoplasia, NGS, amplicon sequencing, whole-exome sequencing, NGS data analysis